Syed Mian

Work

The Francis Crick Institute

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Senior Research Fellow

United Kingdom of Great Britain and Northern Ireland

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University of Roehampton

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Visiting Lecturer

United Kingdom of Great Britain and Northern Ireland

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King's College London

United Kingdom of Great Britain and Northern Ireland

King's College London

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Post Doc Research Associate

United Kingdom of Great Britain and Northern Ireland

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Education

King's College London

United Kingdom of Great Britain and Northern Ireland
PhD

University of Greenwich

United Kingdom of Great Britain and Northern Ireland
BSc (H)

Publications

Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1 -mutated myelodysplasia

Science Translational Medicine

journal-article

Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population

Nature Communications

journal-article

Nature or Nurture? Role of the Bone Marrow Microenvironment in the Genesis and Maintenance of Myelodysplastic Syndromes

Cancers

journal-article

Nature or Nurture? Role of the Bone Marrow Microenvironment in the Genesis and Maintenance of Myelodysplastic Syndromes

Cancers

journal-article

Ectopic Humanized Mesenchymal Niche in Mice Enables Robust Engraftment of Myelodysplastic Stem Cells

Cancer discovery

journal-article

Engraftment of Hematopoietic Cells in Biomaterials Implanted in Immunodeficient Models

Methods in Molecular Biology

book-chapter

Treg sensitivity to FasL and relative IL-2 deprivation drive Idiopathic Aplastic Anemia immune dysfunction

Blood

journal-article

Treg sensitivity to FasL and relative IL-2 deprivation drive Idiopathic Aplastic Anemia immune dysfunction

Blood

journal-article

Impact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7

Leukemia

journal-article

Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells

Blood Cancer Discovery

journal-article

Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells

Blood Cancer Discovery

journal-article

Effect of low-level BCR-ABL1 kinase domain mutations identified by next-generation sequencing in patients with chronic myeloid leukaemia: a population-based study

journal-article

Effect of low-level BCR-ABL1 kinase domain mutations identified by next-generation sequencing in patients with chronic myeloid leukaemia

The Lancet Haematology

journal-article

Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

The Journal of Experimental Medicine

journal-article

Modeling the human bone marrow niche in mice

The Journal of experimental medicine

journal-article

Preclinical modeling of myelodysplastic syndromes

Leukemia

journal-article

Bone Marrow Stem Cells from Patients with Myelodysplastic Syndrome (MDS) Engraft and Migrate in-between the Humanized Niches in Immuno-Compromised Mouse Models

Blood

other

Preclinical modeling of myelodysplastic syndromes

Experimental Hematology

journal-article

Preclinical modeling of myelodysplastic syndromes

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K

journal-article

Versatile humanized niche model enables study of normal and malignant human hematopoiesis

Journal of Clinical Investigation

journal-article

Versatile humanized niche model enables study of normal and malignant human hematopoiesis

Journal of Clinical Investigation

journal-article

Myelodysplastic syndrome can propagate from the multipotent progenitor compartment

Haematologica

journal-article

Functional Characteristics of FAS-L Resistant and IL-2 Deprived Regulatory T Cells (Treg A) in Idiopathic Aplastic Anaemia

Blood

journal-article

Deep-phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Blood

journal-article

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Blood

journal-article

High concordance of genomic and cytogenetic aberrations between peripheral blood and bone marrow in myelodysplastic syndrome (MDS)

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K

journal-article

CSNK1A1 mutations and isolated del(5q) abnormality in myelodysplastic syndrome: a retrospective mutational analysis

The Lancet Haematology

journal-article

CSNK1A1 mutations and isolated del(5q) abnormality in myelodysplastic syndrome

The Lancet Haematology

journal-article

SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment

Nature Communications

journal-article

SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment

Nat Comms

journal-article

High concordance of genomic and cytogenetic aberrations between peripheral blood and bone marrow in myelodysplastic syndrome (MDS)

Leukemia

journal-article

Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome

Blood

journal-article

Somatic mutations identify a sub-group of aplastic anemia patients that progress to myelodysplastic syndrome

Blood

journal-article

Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome

Haematologica

journal-article

Utility of peripheral blood for cytogenetic and mutation analysis in myelodysplastic syndrome

Blood

journal-article

Utility of peripheral blood for cytogenetic and mutation analysis in myelodysplastic syndrome

Blood

journal-article

TP53mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis

British Journal of Haematology

journal-article

TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis

British Journal of Haematology

journal-article

Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome

Haematologica

journal-article

Functional characterization of CD4(+) T cells in aplastic anemia

Blood

journal-article

Correction: B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease

PLoS ONE

journal-article

B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease

PL o S One

journal-article

Functional characterization of CD4+ T cells in aplastic anemia

Blood

journal-article

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

Blood

journal-article

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

Blood

journal-article

Novel TET2 Mutations Associated With UPD4q24 in Myelodysplastic Syndrome

Journal of Clinical Oncology

journal-article

Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome

Journal of Clinical Oncology

journal-article